Objective

To study the chemical interaction between N-(tert-butoxycarbonyl) glycine and 5-Methylfurfurylamine in Methanol-D4 by NMR spectroscopy.

Procedure

One molar methanol-D4 solutions of Boc-Gly-OH (175mg, 1mmol) and 5-methylfurfurylamine (111uL, 1mmol) in CD3OD are prepared in separate 1 dram vials. 800uL of the solutions are used to obtain initial H NMR spectra. Then 400uL of each solution is transfered to a clean nmr tube and shaken vigorously for a few seconds, the reaction is monitored by NMR spectra.

Results

5-Methyl furfurylamine
H NMR
Boc-Gly-OH
H NMR
55A ( 5-Methyl furfurylamine + Boc-Gly-OH)
t = 02min
t = 06min
t = 16min
t = 22min
t = 29min
t = 36min
t = 46min
t = 50min
t = 60min
t = 65min
t = 120min
t = 180min
t = 240min
t = 300min
t = 360min
t = 420min
t = 480min
t = 540min
t = 600min
t = 22h 0min
t = 24h 0min
t = 33h 16min


Discussion

There is almost no change in either components over a period of 33h.

Conclusion

Boc-Glycine and 5-methylfurfurylamine do not react in methanol at room temperature at 0.5M concentration respectively

Log

2007-01-29

10:35 - Made up 1M solutions of Boc-Gly-OH and 5-Methyl furfurylamine in methanol-d4.
11:25 - Obtained H NMR of Boc-Gly-OH and 5-Methyl furfurylamine
12:11 - Added 400uL of Boc-Gly-OH to 400uL of 5-Methylfurfurylamine in an NMR tube.
12:13 - Obtained H NMR (t = 02min)
12:17 - Obtained H NMR (t = 06min)
12:27 - Obtained H NMR (t = 16min)
12:33 - Obtained H NMR (t = 22min)
12:40 - Obtained H NMR (t = 29min)
12:47 - Obtained H NMR (t = 36min)
12:57 - Obtained H NMR (t = 46min)
13:01 - Obtained H NMR (t = 50min)
13:11 - Obtained H NMR (t = 60min)
13:16 - Obtained H NMR (t = 65min)
14:11 - Obtained H NMR (t = 120min)
15:11 - Obtained H NMR (t = 180imn)
16:11 - Obtained H NMR (t = 240min)
17:11 - Obtained H NMR (t = 300min)
18:11 - Obtained H NMR (t = 360min)
19:11 - Obtained H NMR (t = 420min)
20:11 - Obtained H NMR (t = 480min)
21:11 - Obtained H NMR (t = 540min)
22:11 - Obtained H NMR (t = 600min)

2007-01-30

10:11 - Obtained H NMR (t = 22h 0min)
12:11 - Obtained H NMR (t = 24h 0min)
21:27 - Obtained H NMR (t = 33h 16min)

Tags

Boc-Gly-OHInChI=1/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10)
5-methylfurfurylamineInChI=1/C6H9NO/c1-5-2-3-6(4-7)8-5/h2-3H,4,7H2,1H3