Objective

To check the stability of the furan ring of acetamide of 5-methylfurfurylamine from Exp078, in TFA to investigate the behavior of furan containing Ugi products.

Procedure

A solution of acetamide of 5-methylfurfurylamine (153mg, 1mmol) (78C) and pure TFA (1mL) in a round bottom flask, with a condenser was heated for about 30 min under N2.

Results


HNMR of 78C
128A (+TFA 30min reflux)


Discussion


Conclusion

The experiment was aborted. There was no initial HNMR taken to compare to after refluxing.

Log

2007-08-20

17:15 Set up reflux, added TFA (1000uL), acetamide (153mg) and stirrer
17:20 Started heating solution, 2 bubbles/sec of nitrogen
17:22 Reflux began - 5+ drops/sec
17:23 Turned down heat until refluxed at 2 drops/sec
18:00 Took off heat
18:30 Obtained HNMR of solution (128A)