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UC on ChemSpider
Alicia's Masters Thesis
Open Web Drug Dev.
To Do List
Ugi NMR Analysis
To synthesize 3 Ugi products following the
. The compound will contribute towards a library for Falcipain2 inhibitors.
These compunds were ranked 11-13 in the
As described in
Variation to the given procedure: instead of 0.5 mmol of each compound, 0.25 mmol were used in a solution of 250 ul of methanol.
hydroxy(phenyl)acetic acid [Mandelic Acid]
3,4-dihydroxyphenyl acetic acid
4-chlorophenyl acetic acid
None of the attempted Ugi products provided a precipitate, due to the fact that most of those attempted used a phenanthrene-9-carboxaldehyde, which the bottle in stock was found to be problematic, explained in the conclusion. Photographs are not provided because the batteries in the digital camera were dead and I was unable to locate replacements while I was in the lab.
All results are recorded in the
Master Table of all Ugi synthesis attempts
No results - experiment aborted due to a contaminated bottle of phenanthrene-9-carboxaldehyde which was found to be providing false negative results. All compounds will be re-attempted in new experiments.
1:30 Charge acids for vials 4, 5 and 8 1:45 Charge aldehydes for vials 4, 5 and 8 2:00 Charge amines for vials 4, 5 and 8 2:15 Charge isocyanides for vials 4, 5 and 8 2:30 Vortex all vials
3:00 Vials were looked at and determined to have no precipitates
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