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Alicia's Masters Thesis
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To Do List
Ugi NMR Analysis
To synthesize a Ugi product (
) following the
. The compound will contribute towards a library for Falcipain2 inhibitors.
This compunds was ranked 11 in the
link to blog post summary
As described in
ID/ Lib Rank
Density information found on the Sigma-Aldrich website (www.sigmaaldrich.com)
Photos taken directly after all the components were charged and vortexed.
Exp157-11 no flash
Exp157-11 day 1
Exp157/11 day 2
Exp157/11 day 2
The experiment was repeated because Phenanthrene-9-carboxaldhyde which was used in the previous experiment was obtained as a liquid, the
of the liquid does not correspond to the
NMR of the compound
purchased from Sigma-Aldrich.
All results are recorded
Master Table and Workflow Tables
Experiment aborted because a clear solution was not obtained immediately after mixing all reagents.
16:07- Weighed out the Phenanthrene-9-carboxaldehyde.
16:13- Weighed out the phenylacetic acid.
16:19- Charged a vial with 500 ul of methanol.
16:22- Added the cyclohexylamine to the vial.
16:25- Added the phenanthrene-9-carboxaldehyde.
16:30- Added the phenylacetic acid.
16:32- Added the tert-butyl isocyanide and vortexted for one minute. First a chunky opaque solution was observed, and the vial was vortexed further until a homogeneous solution was obtained.
16:40- A photo was taken
after all of the components were mixed. The solution was left to sit for a day at room temperature.
17:45- The solution precipitated white extremely fine crystals. It was placed in ultrasonicator for 5 minutes. A photo of the vial was
also include the Ugi product and InChIKeys for all
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