Skip to main content
Try Wikispaces Classroom now.
Brand new from Wikispaces.
Pages and Files
UC on ChemSpider
Alicia's Masters Thesis
Open Web Drug Dev.
To Do List
Ugi NMR Analysis
To synthesize a
. The compound will contribute towards a library for Falcipain2 inhibitors,
. This compunds was ranked 12 in the
. The purpose of this experiment is to synthesize an anti-malarial compound based on the inhibition of falcipain-2, as described in this
As described in
ID/ Lib Rank
0.5mmol, 41.1 ul
0.5mmol, 90.08 mg
0.5mmol, 52.28 uL
Density information found at the
30 min after mixing
All results are recorded
Master Table and Workflow Tables
Experiment aborted since no homogenous solution was formed. The aldehyde is not very soluble in the solvent, and no clear solution was ever obtained after the aldehyde was added. The insolubility of the aldehyde posed problems in other experiments as well but in others it didn't. This may be because of the reaction that the amine and aldehyde undergo to form a imine. The phenathrene may amine specific, in order to go into solution.
13:05 Added methanol to vial
13:10 Added propylamine to the vial and vortexed for 15 seconds.
13:15 Added aldehyde to vial and vortexed for 15 seconds followed by sonication for 5 minutes.
13:20- Vial was vortexed for 5 minutes, no solution obtained.
13:30 - The acid was added to the vial and vortexed for 15 seconds.
13:31- The vial was vortexed for 5 minutes.
13:36- The vial was sonicated for 5 minutes.
13:44- The isocyanide was added.
13:45 The solution was vortexed for 15 seconds.
13:46 The solution was sonicated for 5 minutes.
13:51 The solution was vortexed for an additional 10 minutes, no solution was obtained.
UgiProduct InChI=1/C32H34N2O4/c1-3-5-16-33-32(36)31(27-20-23-10-6-7-11-24(23)25-12-8-9-13-26(25)27)34(17-4-2)30(35)19-22-14-15-28-29(18-22)38-21-37-28/h6-15,18,20,31H,3-5,16-17,19,21H2,1-2H3,(H,33,36) InChIKey XZPSENWJJNOGKV-UHFFFAOYAP
help on how to format text
Turn off "Getting Started"