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UC on ChemSpider
Alicia's Masters Thesis
Open Web Drug Dev.
To Do List
Ugi NMR Analysis
To synthesize a
. The compound will contribute towards a library for Falcipain2 inhibitors.
This compounds was ranked 29 in the
. The purpose of this experiment is to synthesize an anti-malarial compound based on the inhibition of falcipain-2, as described in this
This experiment is a repeat of Experiment 176 to make sure that I also got a positive result, because every other experiment I have attempted failed to dissolve/ form a precipitate.
As described in
This reaction used
(solid from Sigma-Aldrich)
ID/ Lib Rank
Density information found on the Ugi Chemicals Page in Left Navigation Bar.
Photos taken directly after all the components were charged and vortexed.
All results are recorded
Master Table and Workflow Tables
This experiment demonstrated that I could successfully produce a precipitate from a control Ugi reaction that is known to have a positive result. This also supports my theory that the solubility of phenanthrene-9-carboxaldehyde is dependent on the amine. Furfurylamine has an oxygen in the ring, which increases its reactivity and allows it to participate in hydrogen bonding, thus making it soluble in methanol.
Experiment was successful with the formation of a precipitate. Experiment proved that I am completing experiments correctly. A further discussion of the apparent amine selective solubility of phenanthrene-9-carboxaldehyde is presented
15:44- Weighed out the Phenanthrene-9-carboxaldehyde.
15:50- Weighed out the phenylacetic acid.
15:55- Charged a vial with 1000 ul of methanol.
16:15- Added the furfurylamine to the vial.
16:16 Vortexed vial 1 min
16:17- Added the phenanthrene-9-carboxaldehyde.
1618-Vortexed vial 1 min
16:19- Added the phenylacetic acid.
16:20-Vortexed vial 1 min
16:21- Added the n-butyl isocyanide.
16:35-A clear solution was obtained
16:35- A photo was taken (178A) after the dissolution of all the reagents
13:05 A photo was taken showing the formation of a precipitate (178B)
InChI=1/C3 3H32N2O3/c1-2-3-19-34-33(37)32(30-22-25-14-7-8-16-27(25)28-1 7-9-10-18-29(28)30)35(23-26-15-11-20-38-26)31(36)21-24-12-5- 4-6-13-24/h4-18,20,22,32H,2-3,19,21,23H2,1H3,(H,34,37)
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