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UC on ChemSpider
Alicia's Masters Thesis
Open Web Drug Dev.
To Do List
Ugi NMR Analysis
To synthesize a Ugi Product following the
with phenanthrene-9-carboxaldehyde, cyclohexylamine, mandelic acid and t-butyl isocyanide. The compound will contribute towards a library for Falcipain2 inhibitors.
This compounds was ranked 49 in the
. The purpose of this experiment is to synthesize an anti-malarial compound based on the inhibition of falcipain-2, as described in this
. This experiment was conducted to obtain more data on the solubility of these starting materials in various solvents.
As described in
This reaction used
(solid from Sigma-Aldrich)
This experiment is Ranked 49. It is a repeat of Exp 183 in three different solvents: ethanol, acetonitrile, and dichloromethane.
Exp184-1 is in ethanol, Exp184-2 is in acetonitrile, and Exp184-3 is in dichloromethane.
ID/ Lib Rank
0.5mmol, 76.075 mg
Density information found on the Ugi Chemicals Page in Left Navigation Bar.
Photos taken directly after all the components were charged and vortexed.
Some of the materials were soluble - discuss this. Also your acid might not have been the best choice as a trial run -why?
The starting materials are insoluble in each solvent.
15:33- Charged vial 184-1 with 1000 ul of ethanol.
15:35- Charged vial 184-2 with 1000 ul of acetonitrile.
15:39- Charged vial 184-3 with 1000 ul of dichloromethane.
15:44- Weighed out the Phenanthrene-9-carboxaldehyde and mandelic acid for each of the three samples.
15:55- Added the cyclohexylamine to the vials.
15:59- Vortexed each vial 15 seconds each. Each sample was clear.
16:02- Added the phenanthrene-9-carboxaldehyde to each vial.
16:04- Vortexed vials for 3 minutes each. No clear solutions were obtained for Exp184-1 and Exp184-2. Vial Exp184-3 was clear.
16:14- Added the mandelic acid to each vial.
16:17- Vortexed vial 3 min. No clear solution was obtained.
16:27- Added the t-butyl isocyanide to each vial.
16:30- Vortexed 2 minutes each. No clear solutions were obtained.
16:38- Photos were taken of the vials
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