Objective

To synthesize the top 20 Ugi products from the precipitate prediction library run dated 29th July, these also correspond to the DoUgi
request numbers 112-131

Procedure

Results

Pictures
UCExp245-i
UCExp245-ii
UCExp245-iii
UCExp245-iv
UCExp245-v

HNMR
UCExp245-1A
UCExp245-2A

Spreadsheet- Ugi reaction progress calculator

Spreadsheet UCExp245


Discussion

None of the reactions formed any ppts. These results, incorporated in the CombiUgiResults sheets should enhance the prediction capability of the model.

Conclusion

Solid Ugi products were not obtained for any of the runs.

Log

2009-08-18
13:10 Weighed out a piperonal (1.501g, 10mmol), 3,4-methylenedioxyphenylacetic acid (0.901g, 5mmol) and N-Cbz-L-proline (0.499g, 2mmol).
13:40 Made-up a 5M solution of piperonal (1.501g, 10mmol) in methanol in a 2mL volumetric flask.
13:55 Made-up a 1M solution of 3,4-methylenedioxyphenylacetic acid (0.901g, 5mmol) in methanol in a 1mL volumetric flask.
14:20 Made-up a 2M solution of N-Cbz-Lproline (0.499g, 2mmol) in methanol in a 1mL volumetric flask.
14:45 Labeled 40 half dram vials 1-40
15:40 Pipetted out methanol into vials which needed them see Spreadsheet UCExp245 column labeled '"Extra solvent added (uL)"
16:00 Started pipetting out amine (0.1mmol) to each vial---see spreadsheet for details.
16:20 Pipetted 5M piperonal solution (20uL, 0.1mmol)
16:35 Pipetted out the carboxylic acid solution (0.1mmol) to each vial-see spreadsheet for details.
17:00 Pipetted out isocyanide (0.1mmol) to the vials.
17:30 Vortexed the vials for 10s each.
17:50 Obtained pictures of the vials sitting in well plates. [UCExp245-i, UCExp245-ii, UCExp245-iii]
2009-08-19
18:00 None of the reactions have precipitated so far. Obtained pictures of the vials. [UCExp245-iv, UCExp245-v]
19:35 The reaction mixtures from vials 1 abd 2 were transferred in to clean NMR tubes. CDCl3 (~700uL) was added to them.
20:00 Obtained HNMRs of the reaction mixtures from vials 1 and 2, these are recorded in the results section as UCExp245-1A and UCExp245-2A