ucexp64-i.png

Objective

To reapeat UCExp064
To synthesize a Ugi adduct from 3,4-dimethoxybenzaldehyde, 5-methylfurfurylamine, Benzylisocyanide and Boc-Gly-OH in methanol using Ugi 4CR.

Procedure

Dissolved 3,4-dimethoxybenzaldehyde (Veratradlehyde) (332mg, 2mmol) and 5-methylfurfurylamine(5-MFA) (244uL, 2.2mmol, 10% excess ) in 4mL methanol-d4 in a 4mL volumetric flask, immediately transferred the contents to a 25mL Erlenmeyer flask, The reaction is allowed to sit for about 6 hours without stirring to form the imine.
MS obtained.
Nominal mass
High Res
Elemental analysis
High Res
MS- pdf
Exp064C-IR
Conclusion
Synthesized UCExp064C, successfully.
Log
2010-05-24
Dissolved 332mg (2mmol) of veratraldehyde in methanol, added furfurylamine (244uL), boc glycine 350mg, 2mmol) and Benzylisocyanide(240uL, 2mmol).
Left it to react over night.
2010-05-23
Obtained ppt, filtere, washed with methanol three times.
Dried under vaccum oven.
Obtained NM and IR
MS obtained.
Nominal mass
High Res
Elemental analysis
High Res
MS- pdf
Exp064C-IR