generalugireaction.png


A Ugi reaction is a four component, one pot reaction for the synthesis of a diamide, starting with a primary amine, aldehyde, carboxylic acid and an isocyanide. Usually methanol is used a solvent of choice for this reaction. The diamide may precipitate out as a solid. The back bone of the diamide contains a chiral CH, held between the N of the first amide and carbonyl of the second.
Assignments for the NMR peaks of various Ugi products are provided in the spreadsheet.