Exp055

=Objective= To study the chemical interaction between N-(//tert//-butoxycarbonyl) glycine and 5-Methylfurfurylamine in Methanol-D4 by NMR spectroscopy. =Procedure= One molar methanol-D4 solutions of [|Boc-Gly-OH] (175mg, 1mmol) and [|5-methylfurfurylamine] (111uL, 1mmol) in CD3OD are prepared in separate 1 dram vials. 800uL of the solutions are used to obtain initial H NMR spectra. Then 400uL of each solution is transfered to a clean nmr tube and shaken vigorously for a few seconds, the reaction is monitored by NMR spectra. =Results= [|H NMR] [|H NMR] [|t = 02min] [|t = 06min] [|t = 16min] [|t = 22min] [|t = 29min] [|t = 36min] [|t = 46min] [|t = 50min] [|t = 60min] [|t = 65min] [|t = 120min] [|t = 180min] [|t = 240min] [|t = 300min] [|t = 360min] [|t = 420min] [|t = 480min] [|t = 540min] [|t = 600min] [|t = 22h 0min] [|t = 24h 0min] [|t = 33h 16min]
 * 5-Methyl furfurylamine**
 * Boc-Gly-OH**
 * 55A** ( 5-Methyl furfurylamine + Boc-Gly-OH)

=Discussion= There is almost no change in either components over a period of 33h. =Conclusion= Boc-Glycine and 5-methylfurfurylamine do not react in methanol at room temperature at 0.5M concentration respectively =Log=

2007-01-29
10:35 - Made up 1M solutions of Boc-Gly-OH and 5-Methyl furfurylamine in methanol-d4. 11:25 - Obtained H NMR of Boc-Gly-OH and 5-Methyl furfurylamine 12:11 - Added 400uL of Boc-Gly-OH to 400uL of 5-Methylfurfurylamine in an NMR tube. 12:13 - Obtained H NMR (t = 02min) 12:17 - Obtained H NMR (t = 06min) 12:27 - Obtained H NMR (t = 16min) 12:33 - Obtained H NMR (t = 22min) 12:40 - Obtained H NMR (t = 29min) 12:47 - Obtained H NMR (t = 36min) 12:57 - Obtained H NMR (t = 46min) 13:01 - Obtained H NMR (t = 50min) 13:11 - Obtained H NMR (t = 60min) 13:16 - Obtained H NMR (t = 65min) 14:11 - Obtained H NMR (t = 120min) 15:11 - Obtained H NMR (t = 180imn) 16:11 - Obtained H NMR (t = 240min) 17:11 - Obtained H NMR (t = 300min) 18:11 - Obtained H NMR (t = 360min) 19:11 - Obtained H NMR (t = 420min) 20:11 - Obtained H NMR (t = 480min) 21:11 - Obtained H NMR (t = 540min) 22:11 - Obtained H NMR (t = 600min)

2007-01-30
10:11 - Obtained H NMR (t = 22h 0min) 12:11 - Obtained H NMR (t = 24h 0min) 21:27 - Obtained H NMR (t = 33h 16min) =Tags= [|Boc-Gly-OH][|InChI=1/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10)] [|5-methylfurfurylamine][|InChI=1/C6H9NO/c1-5-2-3-6(4-7)8-5/h2-3H,4,7H2,1H3]

media type="custom" key="19092"