Exp172

== = = =Objective= To synthesize a [|Ugi product] following the EXPLAN005, using [|Methylamine] , [|Tosylmethyl isocyanide], [|formic acid], and [|2-methoxynaphthalene-1-carbaldehyde]. The compound will contribute towards a library for Falcipain2 inhibitors. This compunds was ranked 22 in the [|DEXP014-V1B]file from D-EXP014 .The purpose of this experiment is to synthesize an anti-malarial compound based on the inhibition of falcipain-2, as described in this [|summary post].

=Procedure= As described in Explan005


 * ID/ Lib Rank || Solvent || Aldehyde || Amine || Carboxylic Acid || Isocyanide || Ppt Yes/No ||
 * 168-2/22 || Methanol || 2-methoxynaphthalene-1-carbaldehyde || methylamine, 2.0M solution in methanol. || formic acid || tosylmethyl isocyanide ||  ||
 * Quantity || 1000uL || 0.5mmol, 93.105mg || 0.5mmol, 19.78 ul (error) || 0.5mmol, 18.86ul || 0.5mmol, 97.62 mg ||  ||

Density information found at the [|Ugi Chemicals] page.

= = =Results= all components (Exp172A)** ||  ||
 * **5 min after mixing

All results are recorded Master Table and Workflow Tables. =Discussion= =Conclusion= Experiment aborted due to a miscalculation in the amount of methylamine. A total of 19.78ul were added to the solution where the proper amount is 250ul. =Log=

2008-02-19
13:25 Added methanol to one dram vial 13:30 Added amine 13:31 Vortexed 15 seconds 13:46 Added aldehyde 13:47 Vortex 2 minutes 13:49 Added acid 13:50 Vortexed 15 seconds 14:04 Added isocyanide 14:06 Vortexed 20 seconds 14:11 Took picture **172A** = = =Tags= [|Methylamine] [|InChI=1/CH5N/c1-2/h2H2,1H3][|BAVYZALUXZFZLV-UHFFFAOYAN] [|Tosylmethyl isocyanide] [|InChI=1/C9H9NO2S/c1-8-3-5-9(6-4-8)13(11,12)7-10-2/h3-6H,7H2,1H3][|CFOAUYCPAUGDFF-UHFFFAOYAC] [|formic acid] [|InChI=1/CH2O2/c2-1-3/h1H,(H,2,3)][|BDAGIHXWWSANSR-UHFFFAOYAT] [|2-methoxynaphthalene-1-carbaldehyde] [|InChI=1/C12H10O2/c1-14-12-7-6-9-4-2-3-5-10(9)11(12)8-13/h2-8H,1H3] [|YIQGLTKAOHRZOL-UHFFFAOYAN][|Ugi Product][|InChI=1/C23H24N2O5S/c1-16-8-11-18(12-9-16)31(28,29)14-24-23(27)22(25(2)15-26)21-19-7-5-4-6-17(19)10-13-20(21)30-3/h4-13,15,22H,14H2,1-3H3,(H,24,27)] InChIKey[|RDBIZMTYKUDBFZ]-[|UHFFFAOYAM]