malaria

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Objective
Find, synthesize and test new anti-malarial agents.

Progress

 * 1) The need for anti-malarials was found from a [|search] for: **a pressing need**
 * 2) [|220 target molecules] provided by [|Find-a-Drug]
 * 3) A [|collaborator] for the in vitro testing was found
 * 4) A [|general solid support synthesis was found] that should work for most of this library
 * 5) A much shorter and cheaper [|one pot solution synthesis] was found
 * 6) A database of the compounds needed for the Ugi synthesis has been started here
 * 7) Labwork has started and is reported in the [|Experiments Blog]
 * 8) Lab book summary page started.
 * 9) [|Anti-malarial activity for Ugi products reported] (Jan 25, 2008)
 * 10) Bradley, Jean-Claude, Rosenthal, Philip, Guha, Rajarshi, Mirza, Khalid, and Gut, Jiri. **Open Notebook Science – Falcipain-2 Preliminary Results.** Available from Nature Precedings <[] > (Aug 26, 2008)

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