Exp127

=Objective= To check the stability of the furan ring of the [|Ugi adduct] from [|benzaldehyde], [|5-(Trifluoromethyl)-2-furylmethylamine], [|benzylisocyanide] and [|Boc-Gly-OH] (109C) in TFA to investigate [|the behavior of furan containing Ugi products].

=Procedure= A solution of the [|Ugi product] (54.5mg, 0.1mmol) (109C) and pure TFA (1mL) in a round bottom flask, with a condenser was heated for about 30 min under N2. =Results=

[|t = 4days]
 * 109C** [|HNMR]
 * 127A** ([|Ugi+ TFA 30min reflux])
 * 127B** ([|after 2hr reflux])

=Discussion=

=Conclusion=

=Log=

2007-08-20
17:15 Set up reflux, added TFA (1000uL), Ugi product (54.5mg) and stirrer 17:20 Started heating, 2 bubbles/sec of nitrogen 17:22 Reflux began - 1 drop/sec 18:00 Took off heat 18:30 Obtained NMR of **127A.** The solution was left at room temperature (exposed to air)

2007-08-24
15:51 Obtained HNMR of 127A (4days) 17:10 Ran nitrogen through experimental setup 17:12 Began heating solution 17:22 Started to reflux at 1 drop/sec 17:24 Solution began refluxing at 2 drops/sec 17:35 Solution refluxing at 3-4 drops/sec, turned down heat 17:40 Solution reluxing at 1-2 drops/sec 19:15 Took solution off of heat 19:35 Obtained HNMR of 127B in CDCl3