Exp161

== =Objective= To synthesize a [|Ugi products] following the EXPLAN005. The compound will contribute towards a library for Falcipain2 inhibitors. This compunds was ranked 14 in the [|DEXP014-V1B]file from D-EXP014. =Procedure= As described in Explan005

carboxaldehyde || furfurylamine || hydroxy(phenyl)acetic acid [Mandelic acid] (//**is this one enantiomer or racemic?**//) dl-mandelic acid || tert-butylisocyanide ||  || (density=0.735g/ml) ||  ||
 * ID/ Lib Rank || Solvent || Aldehyde || Amine || Carboxylic Acid || Isocyanide || Ppt Yes/No ||
 * 157/14 || Methanol || Phenanthrene-9-
 * Quantity || 1000uL || 0.5mmol, 103.1mg || .5mmol, 44.18 ul || 0.5mmol, 76.075 mg || 0.5mmol, 56.5uL

Density information found on the Sigma-Aldrich website (www.sigmaaldrich.com)

= = =Results=

All results are recorded Master Table and Workflow Tables.

=Conclusion= Experiment aborted because a clear solution was never obtained immediately after mixing all reagents or the addition of extra solvent. However no pics were taken to document this so the experiment will have to be repeated. =Log=

2008-01-24
15:22- Methanol added to one dram vial. 15:23- Furfurylamine was added to the vial and solution was vortexed for 20 seconds. 15:24-Weighed out Phenanthrene-9-carboxaldehyde. 15:26- Added Phenanthrene-9-carboxaldehyde to solution and vortexed for 20 seconds, a homogenous solution was not formed thus the solution was sonicated for 5 minutes, and still no homogeneous solution was formed. 15:32- Weighed out Mandelic acid. 15:34- Added Mandelic acid and vortexed for 20 seconds, no homogeneous solution was formed thus the solution was sonicated for 5 minutes. 15:41- Isocyanide was added to the solution and the vial was vortexed for 20 seconds and sonicated for 5 minutes. 15:47- No homogenous mixture was obtained. 15:50- 1000ul of methanol was added to try and help the mixture go into solution, and vortexed for 5 minutes. 15:55- No solution was obtained.

=Tags= [|Phenanthrene-9-carboxaldehyde][|InChI=1/C15H10O/c16-10-12-9-11-5-1-2-6-13(11)15-8-4-3-7-14(12)15/h1-10H] InChIKey [|QECIGCMPORCORE]-[|UHFFFAOYAE] [|Furfurylamine] [|InChI=1/C5H7NO/c6-4-5-2-1-3-7-5/h1-3H,4,6H2]InChIKey [|DDRPCXLAQZKBJP]-[|UHFFFAOYAX] [|tert-butyl isocyanide][|InChI=1/C5H9N/c1-5(2,3)6-4/h1-3H3] InChIKey [|FAGLEPBREOXSAC]-[|UHFFFAOYAL] [|Mandelic acid] [|InChI=1/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11)/t7-/m0/s1] InChIKey [|IWYDHOAUDWTVEP]-[|UHFFFAOYAD] [|UgiProduct InChI=1/C33H32N2O4/c1-33(2,3)34-31(37)29(28-20-23-14-7-8-16-25(23)26-17-9-10-18-27(26)28)35(21-24-15-11-19-39-24)32(38)30(36)22-12-5-4-6-13-22/h4-20,29-30,36H,21H2,1-3H3,(H,34,37)] InChIKey [|KWDYVEIXHGZXHC]-[|UHFFFAOYAW]