Exp169

[[image:exp169a.gif]]
=Objective= To synthesize a [|Ugi product] (//**incorrect**//) following the EXPLAN005 by using [|Phenanthrene-9-carboxaldehyde], [|tert-butylisocyanide], [|cyclohexylamine], and [|3,4-methylenedioxyphenylacetic acid]. The compound will contribute towards a library for Falcipain2 inhibitors.This compunds was ranked 23 in the [|DEXP014-V1B]file from D-EXP014. =Procedure= As described in Explan005

carboxaldehyde || cyclohexylamine || 3,4 methylenedioxyphenylacetic acid || tert-butylisocyanide || N/A || (density=0.867g/ml) || 0.5mmol, 90.08 mg || 0.5mmol, 56.5uL (density=0.735g/ml) ||  ||
 * ID/ Lib Rank || Solvent || Aldehyde || Amine || Carboxylic Acid || Isocyanide || Ppt Yes/No ||
 * 169/23 || Methanol || Phenanthrene-9-
 * Quantity || 1000uL || 0.5mmol, 103.1mg || 0.5mmol, 57.2uL

Density information found on the [|Ugi Chemicals] page. =Results= Photos taken directly after all the components were charged and vortexed.
 * 169A** (after mixing)

No dissolution could be achieved during the additions even with 30 minutes of vortexing as well as further dilution.

=Discussion= All results are recorded Master Table and Workflow Tables =Conclusion= Experiment aborted because a clear solution was never obtained. =Log=

2008-02-07
12:23- Added methanol to one dram vial. 12:26- Added amine to vial and vortexed for 15 seconds. 12:28- Added aldehyde to vial and vortexed for 10 minutes. No clear solution was obtained. 12:40-Added acid to vial and vortexed for 10 mintues. Very difficult to achieve solution, no solution was obtained. 12:52- Added isocyanide to vial and vortexed for 10 minutes. No solution was obtained. 1:02- Picture **169**A was taken.

=Tags= [|Phenanthrene-9-carboxaldehyde][|InChI=1/C15H10O/c16-10-12-9-11-5-1-2-6-13(11)15-8-4-3-7-14(12)15/h1-10H]InChIKey [|QECIGCMPORCORE]-[|UHFFFAOYAE] [|tert-butylisocyanide][|InChI=1/C5H9N/c1-5(2,3)6-4/h1-3H3] InChIKey [|FAGLEPBREOXSAC]-[|UHFFFAOYAL] [|cyclohexylamine][|InChI=1/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2]InChIKey[|IFYLVUHLOOCYBG]-[|UHFFFAOYAD] [|3,4-methylenedioxyphenylacetic acid] [|InChI=1/C9H8O4/c10-9(11)4-6-1-2-7-8(3-6)13-5-12-7/h1-3H,4-5H2,(H,10,11)][|InChIKeyODVLMCWNGKLROU]-[|UHFFFAOYAB] [|Ugi Product] [|InChI=1/C3 ​4H38N2O2/c​1-34(2,3)3​5-33(38)32​(30-23-25-​16-10-11-1​9-27(25)28​ -20-12-13-​21-29(28)3​0)36(26-17​-8-5-9-18-​26)31(37)2​2-24-14-6-​ 4-7-15-24/​h4,6-7,10-​16,19-21,2​3,26,32H,5​,8-9,17-18​,22H2,1-3H​ 3,(H,35,38​)]InChIKey[|NYDTYYMZLJAMKH]-[|UHFFFAOYAI] (//**incorrect**//)