Exp136

=Objective= To synthesize one Ugi adduct following the EXPLAN005. The compound will contribute toward a library for enoyl reductase inhibitors.

=Procedure= A Ugi reaction was carried out in a 1 dram vial labeled 1. Vial 1 contained methanol (500uL), o-vanillin (0.5mmol, 76.1mg), benzylamine (0.5mmol, 53.6uL), Boc-Trp-OH (0.5mmol, 152.1mg), and n-pentylisocyanide (0.5mmol, 62.9 uL), added in that order.

=Results= The results show that no precipitate was formed after 24 hours.

=Discussion= This Ugi Product will be recorded as "No Precipitate Formed" on our records of tested Ugi products. Until further testing proves otherwise, we must assume this as a negative Ugi Reaction.

=Conclusion= It is difficult to conclude anything from this experiment other than that this particular Ugi Reaction showed no success in forming a precipitate. There is no noticeable pattern as of now on which Ugi reactions will be positive and yield precipitates. (**//No visual proof provided in the results section - experiment will have to be repeated showing pics immediately after mixing and several days later//**) =Log=

2007-10-01
16:10: Weighed out o-Vanillin (76.1mg) directly into dram vial. 16:15: Weighed out Boc-Trp-OH (152.1mg) on weighing paper 16:17: Added methanol (500uL) into the dram vial, followed by 30 seconds vortexing. 16:20: Added amine into the dram vial, followed by 15 seconds vortexing. 16:23: Added acid into the dram vials, followed by 30 second vortexing. 16:27: Added isocyanide into the dram vials followed by 15 second vortexing. 16:28: Let vials sit in fume hood overnight

=Tags= [|o-vanillin] [|InChI=1/C5H11NS2.Na/c1-3-6(4-2)5(7)8;/h3-4H2,1-2H3,(H,7,8);/q;+1/p-1/fC5H10NS2.Na/q-1;m] [|Boc-trp-OH] [|InChI=1/C16H20N2O4/c1-16(2,3)22-15(21)18-13(14(19)20)8-10-9-17-12-7-5-4-6-11(10)12/h4-7,9,13,17H,8H2,1-3H3,(H,18,21)(H,19,20)] [|benzylamine] [|InChI=1/C7H9N/c8-6-7-4-2-1-3-5-7/h1-5H,6,8H2] [|n-pentylisocyanide] [|InChI=1/C6H11N/c1-3-4-5-6-7-2/h3-6H2,1H3]