Exp144

=Objective= To synthesize 3 Ugi products following the EXPLAN005. The compound will contribute towards a library for Falcipain2 inhibitors. These compunds were ranked 144, 146, and 147 in the [|DEXP014-V1B] file from D-EXP014. = = =Procedure= As described in Explan005
 * **Comp ID**/ **Lib Rank** || **Aldehyde** || **Amine** || **Carboxylic Acid** || **Isocyanide** || **Ppt Yes/No** ||
 * 144-1/144 || Benzaldehyde (0.25mmol, 25.3uL) || Benzylamine (0.25mmol, uL) || p-chlorobenzoic acid (0.25mmol, 34.1uL) || Tosylmethyl isocyanide (0.25mmol, 38.8mg) || No ||
 * 144-2/146 || 3-hydroxybenzaldehyde (0.25mmol, 30.5mg) || Benzylamine (0.25mmol, 27.4uL) || p-chlorobenzoic acid (0.25mmol, 34.1uL) || Tosylmethyl isocyanide (0.25mmol, 38.8mg) || No ||
 * 144-3/147 || Phenanthrene-9-carboxaldehyde (0.25mmol, 42.4uL) || Methylamine (0.25mmol, 12.2uL) || p-chlorobenzoic acid (0.25mmol, 34.1uL) || n-butylisocyanide (0.25mmol, 26.1uL) || No ||

=Results= All results are recorded in the [|Master Table of all Ugi synthesis attempts]

=Discussion=

=Conclusion= Experiment aborted - no results provided. =Log=

2007-11-07
15:45: Weighed out p-chlorobenzoic acid, tosylmethyl isocyanide, and 3-hydroxybenzaldehyde on weighing paper 15:50: Added methanol (500uL) into the dram vials, followed by 30 seconds vortexing. 15:53: Added aldehyde into the dram vials, followed by 15 seconds vortexing. 15:55: Added amine into the dram vials, followed by 30 seconds vortexing. 15:57: Added acid into the dram vials followed by 15 seconds vortexing 16:01: Added isocyanide into dram vials followed by 15 seconds vortexing 16:03: Vials were kept in hood overnight

2007-11-08
12:10: Vials were looked at and determined to have no precipitate

=Tags= [|n-butylisocyanide] [|InChI=1/C5H9N/c1-3-4-5-6-2/h3-5H2,1H3] [|phenanthrene-9-carboxaldehyde][|InChI=1/C15H10O/c16-10-12-9-11-5-1-2-6-13(11)15-8-4-3-7-14(12)15/h1-10H] [|benzylamine][|InChI=1/C7H9N/c8-6-7-4-2-1-3-5-7/h1-5H,6,8H2] [|tosylmethylisocyanide] [|InChI=1/C9H9NO2S/c1-8-3-5-9(6-4-8)13(11,12)7-10-2/h3-6H,7H2,1H3] [|p-chlorobenzoic acid] [|InChI=1/C7H5ClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)/f/h9H] [|3-hydroxybenzaldehyde] [|InChI=1/C7H6O2/c8-5-6-2-1-3-7(9)4-6/h1-5,9H] [|benzaldehyde] [|InChI=1/C7H6O/c8-6-7-4-2-1-3-5-7/h1-6H] [|methylamine] [|InChI=1/CH5N/c1-2/h2H2,1H3]