Exp140

=Objective= To synthesize two Ugi products following the EXPLAN005. The compound will contribute towards a library for Falcipain2 inhibitors. These compunds were ranked 151 and 152 in the [|DEXP014-V1B] file from D-EXP014. =Procedure= As described in Explan005 (0.25mmol, 29.7uL) || 5-methylfurfurylamine (0.25mmol, 27.9L) || 4-nitrobenzoic acid (0.25mmol, 41.8mg) || Tosylmethylisocyanide (0.25mmol, 48.8mg) ||  || (0.25mmol, 49.36mg) || Furfurylamine (0.25mmol, 22.1uL) || 4-Chlorophenylacetic acid (0.25mmol, 50.39mg) || n-butylisocyanide (0.25mmol, 26.1uL) || no ||
 * **Comp ID**/ **Lib Rank** || **Aldehyde** || **Amine** || **Carboxylic Acid** || **Isocyanide** || **Ppt Yes/No** ||
 * 140a/__151__ || 5-bromo-2-thiophenecarboxaldehyde
 * 140b/__152__ || 2-chloro-5-nitrobenzaldehyde

=Results= For experiment 140a/151 the aldehyde had already changed from liquid to solid before the experiment was started. The change in the aldehyde caused the components to never fully go into solution. **//(does this mean that there was no clear solution at the imine formation stage? if so write aldehyde insoluble in the table) - include pics next time//** For experiment 140b/152 there was no solid product formed.

=Discussion= All results are recorded in the [|Master Table of all Ugi synthesis attempts] =Conclusion=

=Log=

2007-10-19

 * //The log must ALWAYS be recorded on the wiki by the end of the day//**

=Tags= add inchi