Exp129

=Objective= To check the stability of the furan ring of [|acetamide of 5-methylfurfurylamine] from Exp078, in TFA to investigate [|the behavior of furan containing Ugi products].

=Procedure= A solution of [|acetamide of 5-methylfurfurylamine] (153mg, 1mmol) (78C) and pure TFA (1mL) in a (**//what size? - this is a very small amount of solution//**) round bottom flask, with a condenser was heated for about 30 min (**//this does not match log//**) under N2.

=Results=

[|HNMR of 78C] [|t -13min] (room temp)
 * 129A** (+ CDCl3)
 * 129B** ([|after 2hr reflux])

=Discussion=

=Conclusion=

=Log=

2007-08-24
16:23 Added TFA (1ml) to the acetamide (78C) (153mg), this is 129A 16:35 Obtained HNMR of 129A (12min) 17:10 Started running N2. 17:12 Started heating the round bottom flask containing 129A. 17:20 Solution started refluxing at 2 drops/sec 17:22 Refluxed at 3 drops/sec, turned down heat 17:27 Remained refluxing at 1-2 drops/sec 19:15 Took solution off of heat, added 300uL of solution to small vial to cool, this is 129B 19:40 Obtained HNMR of 129B