Exp025GSreport

A possible mechanism for the formation of Dopal from Adrenaline.
In experiment 025, in the synthesis of [|dopal] from [|adrenaline]:

H3PO4 performs a posible E-1 reaction with adrenaline in order to convert it to Dopal. One of the possible mechanisms is shown below.

Through this mechanism, an enamine is created in step 3. B represents a base in solution, using H3PO4, B represents H2PO4-. Curly arrows originating between atoms signify they originate from the bond between the two atoms. Dehydration of an alcohol and hydrolysis of an imine are two processes that occur in this proposed mechanism.




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