Exp056

=Objective= To study the chemical interaction between N-(//tert//-butoxycarbonyl) -L-methionine and 5-Methylfurfurylamine in Methanol-D4 by NMR spectroscopy. =Procedure= One molar methanol-D4 solutions of[| N-(tert)-butoxycarbonyl)-L-methionine] (249mg, 1mmol) and [|5-methylfurfurylamine] (111uL, 1mmol) in CD3OD are prepared in separate 1 dram vials. 800uL of the solutions are used to obtain initial H NMR spectra. Then 400uL of each solution is transfered to a clean nmr tube and shaken vigorously for a few seconds, the reaction is monitored by H NMR spectra. =Results= [|H NMR] [|H NMR] [|t = 02min] [|t = 05min] [|t = 11min] [|t = 19min] [|t = 25min] [|t = 32min] [|t = 43min] [|t = 49min] [|t = 56min] [|t = 60min] [|t = 120min] [|t = 180min] [|t = 240min] [|t = 300min] [|t = 360min] [|t = 420min] [|t = 480min] [|t = 540min] [|t = 600min] [|t = 22h 0min] [|t = 24h 0min] [|t = 33 05min]
 * 5-Methyl furfurylamine**
 * Boc-Met-OH**
 * 55A** ( 5-Methyl furfurylamine + Boc-Met-OH)

=Discussion= There is almost no change in either components over a period of 33h. =Conclusion= Boc-Methionine and 5-methylfurfurylamine do not react in methanol at room temperature at 0.5M concentration respectively =Log=

2007-01-29
10:45 - Made up 1M solutions of Boc-Met-OH and 5-Methyl furfurylamine in methanol-d4. 11:35 - Obtained H NMR of Boc-Met-OH and 5-Methyl furfurylamine 12:18 - Added 400uL of Boc-Gly-OH to 400uL of 5-Methylfurfurylamine in an NMR tube. 12:20- Obtained H NMR (t = 02min) 12:23 - Obtained H NMR (t = 05min) 12:29- Obtained H NMR (t = 11min) 12:37- Obtained H NMR (t = 19min) 12:43 - Obtained H NMR (t = 25min) 12:50 - Obtained H NMR (t = 32min) 12:54 - Obtained H NMR (t = 43min) 13:07 - Obtained H NMR (t = 49min) 13:14 - Obtained H NMR (t = 56min) 13:18 - Obtained H NMR (t = 60min) 14:18 - Obtained H NMR (t = 120min) 15:18 - Obtained H NMR (t = 180min) 16:18 - Obtained H NMR (t = 240min) 17:18 - Obtained H NMR (t = 300min) 18:18 - Obtained H NMR (t = 360min) 19:18 - Obtained H NMR (t = 420min) 20:18 - Obtained H NMR (t = 480min) 21:18 - Obtained H NMR (t = 540min) 22:18 - Obtained H NMR (t = 600min)

2007-01-30
10:18 - Obtained H NMR (t = 22h 0min) 12:18 - Obtained H NMR (t = 24h 0min) 21:23 - Obtained H NMR (t = 33h 05min) =Tags= [|Boc-Methionine] [|InChI=1/C10H19NO4S/c1-10(2,3)15-9(14)11-7(8(12)13)5-6-16-4/h7H,5-6H2,1-4H3,(H,11,14)(H,12,13)] [|5-methylfurfurylamine][|InChI=1/C6H9NO/c1-5-2-3-6(4-7)8-5/h2-3H,4,7H2,1H3]

media type="custom" key="19090"