Exp139

=Objective= To synthesize ten Ugi products following the EXPLAN005. The compound will contribute towards a library for Falcipain2 inhibitors. These compunds were ranked 51-61 in the [|DEXP014-V1B] file from D-EXP014. =Procedure= As described in Explan005 (**please fill in the amounts of each of the chemicals used)** (0.25mmol,0.498 ) || Propylamine (0.25mmol, 22.4ul) || Benzoic Acid (0.25mmol, 24.7ul) || n-butylisocyanide (0.25mmol,23.7uL) ||  || (0.25mmol, 0.506) || Benzylamine (0.25mmol, 22.5uL) || Hippuric Aicd (0.25mmol, 22.8uL) || t-butylisocyanide (0.25mmol, 220.1uL) ||  || (0.25mmol,xxuL) || cyclehexylamine (0.25mmol,xxuL) ||  || tosylisocyanide (0.25mmol,xxuL) ||  || (0.25mmol,0.4866) || hexylamine- (0.25mmol,24.6uL) || 2-hydroxyacetic acid (0.25mmol,18.6uL) || n-butylisocyanise (0.25mmol 21.5uL) ||  || (0.25mmol,xxul) || 3-chloroaniline (0.25mmol,25.5ul) || phenylacetic acid (0.25mmol,21.8ul) || t-butylisocyanide (0.25mmol, 21.6uL) ||  || (0.25mmol,0.8201ul) || propylamine (0.25mmol,24.8ul) || 2-chlorobenzoic acid (0.25mmol,21.4ul) || t-butylisocyanide (0.25mmol, 19.5uL) ||||  || (0.25mmol, 0.562ug) || methylamine (0.25mmol,22.5ul) || hippuric acid (0.25mmol,20.8ul) || tosylmethylisocyanide ||  || (0.25mmol,xxul) || tosylmethylisocyanide ||  ||
 * **Comp ID**/ **Lib Rank** || **Aldehyde** || **Amine** || **Carboxylic Acid** || **Isocyanide** || **Ppt Yes/No** ||
 * 139a/51 || Phenanthrene-9-carboxaldehyde
 * 139b/52 || 3-methoxybenzaldehyde
 * 139bc53 || phenanthrene-9-caroxaldehyde
 * 139d/54 || phenanthrene-9-carboxaldehyde
 * 139e/55 || phenanthrene-9-carboxaldehyde
 * 139f/56 || phenenthrene-9-carboxaldehyde
 * 139g/57 || Phenanthrene-9-carboxaldehyde
 * 139h/58 || Phenanthrene-9-carboxaldehyde || 1-phenylmethanamine || 4-chlorophenyl acetic acid
 * 139i/59 || Phenanthrene-9-carboxaldehyde || furfurylamine || 3,4-dihydroxyphenyl acetic acid || t-butylisocyanide ||  ||
 * 139j/60 || Phenanthrene-9-carboxaldehyde || benzylamine || phenyl acetic acid || t-butylisocyanide ||  ||
 * 139k/61 || 2-methoxy-1-naphthaldehyde || methylamine || furoic acid || toluene-4-sulfonylmethyl isocyanide ||  ||

=Results=

the vials were checked 24 hour later and no precipitate was observed in any of the solutions prepared. =Discussion= All results are recorded in the [|Master Table of all Ugi synthesis attempts] =Conclusion= Experiment aborted because phenanthrene-9-carboxaldehyde bad and no results recorded. =Log=

2007-10-19
2:15 methanol was added to all vials. 3:00 solid reagents were weighed out for all experiments. 3:30 reagents were added to vials in the order described by above procedure. 5:00 vials containing solutions were left overnight =Tags= //add inchi of all the compounds involved.//
 * 1:30 all reagents for experiment 139 were collected.**