Exp141

=Objective= To synthesize two Ugi products following the EXPLAN005. The compound will contribute toward a library for Falcipain2 inhibitors. These compounds were ranked 101 and 105 in the [|DEXP014-V1B]

=Procedure= As described in Explan005 (0.25mmol, 42.4uL) || Furfurylamine (0.25mmol, 22.1uL) || Hippuric acid (0.25mmol, 44.79mg) || Butyl isocyanide (0.25mmol, 26.1uL) || Void || (0.25mmol, 22.1uL) || Hippuric acid (0.25mmol, 44.79mg) || t-butylisocyanide (0.25mmol, 28.3uL) || Void ||
 * **Comp ID**/ **Lib Rank** || **Aldehyde** || **Amine** || **Carboxylic Acid** || **Isocyanide** || **Ppt Yes/No** ||
 * 142-1/101 || phenanthrene-9-carboxaldehyde
 * 142-2/105 || phenanthrene-9-carboxaldehyde(0.25mmol, 42.4uL) || Furfurylamine

=Results= All results are recorded in the [|Master Table of all Ugi synthesis attempts]

=Discussion= An error was made in the amount of hippuric acid added to the two samples. Due to the excess amount of hippuric acid added, the samples formed an insoluble, cloudy mixture. The results were void for this experiment

=Conclusion= The results of this experiment are void as the measurements made for the hippuric acid were erroneous. Instead of 44.79 mg, 447.9 mg were added by accident to the mixture. This resulted in a precipitate that was due to insolubility rather than actual precipitate formed via reaction.

=Log=

2007-10-26
16:25: Weighed out hippuric acid (44.79 mg) on weighing paper 16:30: Added methanol (500uL) into the dram vials, followed by 30 seconds vortexing. 16:32: Added aldehyde into the dram vials, followed by 15 seconds vortexing. 16:34: Added amine into the dram vials, followed by 30 second vortexing. 16:36: Added acid into the dram vials followed by 15 second vortexing 16:40: Added isocyanide into dram vials followed by 15 second vortexing. 16:45: Let vials sit in fume hoods tonight

=Tags= [|n-butylisocyanide] [|InChI=1/C5H9N/c1-3-4-5-6-2/h3-5H2,1H3] [|phenanthrene-9-carboxaldehyde][|InChI=1/C15H10O/c16-10-12-9-11-5-1-2-6-13(11)15-8-4-3-7-14(12)15/h1-10H] [|t-butylisocyanide][|InChI=1/C5H9N/c1-5(2,3)6-4/h1-3H3] [|furfurylamine] [|InChI=1/C5H7NO/c6-4-5-2-1-3-7-5/h1-3H,4,6H2] [|hippuric acid] [|InChI=1/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)/f/h10-11H]