Exp142

=Objective= To synthesize two Ugi products following the EXPLAN005. The compound will contribute toward a library for Falcipain2 inhibitors. This experiment is a re-do of Exp141. These compounds were ranked 101 and 105 in the [|DEXP014-V1B]

=Procedure= As described in Explan005 (0.25mmol, 42.4uL) || Furfurylamine (0.25mmol, 22.1uL) || Hippuric acid (0.25mmol, 44.8mg) || Butyllisocyanide (0.25mmol, 26.1uL) || No || (0.25mmol, 22.1uL) || Hippuric acid (0.25mmol, 44.8mg) || t-butylisocyanide (0.25mmol, 28.3uL) || No ||
 * **Comp ID**/ **Lib Rank** || **Aldehyde** || **Amine** || **Carboxylic Acid** || **Isocyanide** || **Ppt Yes/No** ||
 * 141-1/__101__ || phenanthrene-9-carboxaldehyde
 * 141-2/__105__ || phenanthrene-9-carboxaldehyde (0.25mmol, 42.4uL) || Furfurylamine

=Results= All results are recorded in the [|Master Table of all Ugi synthesis attempts]

__Picture of solutions soon after the addition of all components (**142A**)__ =Discussion= This time, the solubility issue was resolved. Unfortunately, no precipitate formation occurred. An important lesson, however, did come from these experiments. It elucidates how important it is to be careful during the measuring periods of sample preparation. Full attention is required when weighing out the samples because even if one compound is improperly weighed, it can lead to erroneous results. Fortunately, the insolubility in this case allowed us to catch the mistake. However, in the future, the error may not be as easy to spot. = = = = =Conclusion= There was no precipitate (**//you need to provide evidence for this//**) shown in any of the vials. It confirms that Experiment 141 showed precipitate due to the insolubility of excess hippuric acid and not the actual formation of precipitate via reaction.
 * //why did you delete the request to put pic 142B? - the log says it exists and you need it to support your conclusion//**

=Log=

2007-10-31
16:25: Weighed out hippuric acid (44.79 mg) on weighing paper 16:30: Added methanol (500uL) into the dram vials, followed by 30 seconds vortexing. 16:32: Added aldehyde into the dram vials, followed by 15 seconds vortexing. 16:34: Added amine into the dram vials, followed by 30 seconds vortexing. 16:36: Added acid into the dram vials followed by 15 seconds vortexing 16:40: Added isocyanide into dram vials followed by 15 seconds vortexing 16:42: Picture of dram vials was taken **142A** 16:44: Vials were kept in hood overnight

2007-11-01
13:00: Vials were looked at and determined to have no precipitate 13:02: Picture of dram vials was taken **142B**

=Tags= [|n-butylisocyanide] [|InChI=1/C5H9N/c1-3-4-5-6-2/h3-5H2,1H3] [|phenanthrene-9-carboxaldehyde][|InChI=1/C15H10O/c16-10-12-9-11-5-1-2-6-13(11)15-8-4-3-7-14(12)15/h1-10H] [|t-butylisocyanide][|InChI=1/C5H9N/c1-5(2,3)6-4/h1-3H3] [|furfurylamine] [|InChI=1/C5H7NO/c6-4-5-2-1-3-7-5/h1-3H,4,6H2] [|hippuric acid] [|InChI=1/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)/f/h10-11H]