Exp124

== =Objective= To synthesize two Ugi adducts. The compounds will contribute toward a library for enoyl reductase inhibitors. =Procedure= A solution of //o//-Vanillin (76.0mg, 0.5 mmol) and 5-methylfurfurylamine (55.7uL, 0.5 mmol) was prepared in methanol a 1ml volumetric flask to form an imine. After three hours Boc-Tryptophan (152.1mg, 0.5mmol), and 1-Butylisocyanide (52.3uL 0.5 mmol) was added to the preformed imine. The solution was left at room temperature overnight. A crystalline product obtained was centrifuges washed and recrystallized with methanol (5mL). A solution of Veratraldehyde (83.0, 0.5 mmol) and 5-methylfurfurylamine (55.7uL, 0.5 mmol) was prepared in methanol a 1ml volumetric flask to form an imine. After three hours Boc-Tryptophan (152.17mg, 0.5mmol), and 1-Butylisocyanide (52.3uL 0.5 mmol) was added to the preformed imine. The solution was left at room temperature overnight. A crystalline product obtained was centrifuged, washed and recrystallized from methanol (5mL). =Results=

[| HNMR] [| CNMR] [|H NMR] [|C NMR] [| HNMR] [| CNMR] [|HNMR] [| CNMR] [|H NMR] [|C NMR]
 * //o//-Vanillin**
 * 5-methylfurfurylamine**
 * Boc-Tryptophan**
 * 1-Butylisocyanide**
 * Veratraldehyde**

=Conclusion= Experiment aborted. =Log=

2007-08-16
15:52 Made up a solution of Veratraldehyde and 5-Methylfurfurylamine in methanol in a 1ml volumetric flask 15:52 Made up a solution of o-Vainillin and 5-Methylfurfurylamine in methanol in a 1ml volumetric flask. 19:02 Completed the addition of Boc-Tryptophan and n-butyl isocyanide.