Exp138

Objective
To synthesize 3 Ugi products following the EXPLAN005. The compound will contribute towards a library for Falcipain2 inhibitors. These compunds were ranked 11-13 in the [|DEXP014-V1B] file from D-EXP014. =Procedure= As described in Explan005 Variation to the given procedure: instead of 0.5 mmol of each compound, 0.25 mmol were used in a solution of 250 ul of methanol.
 * **Comp ID**/ **Lib Rank** || **Aldehyde** || **Amine** || **Carboxylic Acid** || **Isocyanide** || **Ppt Yes/No** ||
 * 138-1/11 || Phenanthrene-9-carboxaldehyde || Cyclohexylamine || Phenylacetic acid || t-butylisocyanide || aborted ||
 * 138-2/12 || Phenanthrene-9-carboxaldehyde || Propylamine || 3,4-methylenedioxyphenyl acetic acid || n-butylisocyanide || aborted ||
 * 138-3/13 || benzaldehyde || 5-methylfurfurylamine || 2,3-dihydroxybenzoic acid || Tosylmethyl isocyanide || aborted ||

=Results= None of the attempted Ugi products provided a precipitate, due to the fact that most of those attempted used a phenanthrene-9-carboxaldehyde, which the bottle in stock was found to be problematic, explained in the conclusion. Photographs are not provided because the batteries in the digital camera were dead and I was unable to locate replacements while I was in the lab. =Discussion= All results are recorded in the [|Master Table of all Ugi synthesis attempts] =Conclusion= No results - experiment aborted due to a contaminated bottle of phenanthrene-9-carboxaldehyde which was found to be providing false negative results. All compounds will be re-attempted in new experiments. =Log=

2007-10-19
2:10 Charge reagents into vial 1 2:25 Vortex vial 1 3:00 Charge reagents for vial 2 3:15 Vortex vial 2 3:15 Charge reagents for vial 3 3:30 Vortex vial 3

2007-10-21
1:20 Vials were looked at and determined to have no precipitates

=Tags= //add inchi of all the compounds involved.//